The tumor antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters

Thank you for submitting your manuscript for consideration by The EMBO Journal. It has been now been evaluated by three referees and I enclose their reports below. As you will see the referees find the identification of PRAME as a Cullin based ubiquitin ligase and its role at promoters to be potentially interesting and important although they do need some further experimental analysis to make it suitable for The EMBO Journal. There are a number of experiments that are suggested, however, I think that the points that are most important to address are if the PRAME NF-Y interaction is direct and if NF-Y is required for the recruitment of PRAME to promoters. Theses two related issues need to be addressed for the manuscript to be further considered for publication in The EMBO Journal, should you be able to achieve this we would be happy to consider a revised version of the manuscript.